Trial of mGluR5 Antagonist AFQ056 in Patients with Fragile X

Tuesday, January 4, 20112comments

Trial of mGluR5 Antagonist AFQ056 in Patients with Fragile X

U.S. medical centers are recruiting men and women with Fragile X, ages 18-45, for a large-scale Phase IIb clinical trial. A trial involving children is planned to follow.

The randomized, double-blind, placebo-controlled clinical study sponsored by Novartis is designed to assess whether AFQ056 is safe and effective in treating the behavioral symptoms of Fragile X Syndrome. AFQ056 is an mGluR5 antagonist, which decreases mGluR5 activity in the brain. The trial involves 9 visits over 20 weeks, with many safety measures like blood draws and ECGs.

Detailed information is available at www.clinicaltrials.gov.
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