Genes linked to migraine discovered - TRPM8, LRP1 and PRDM16 |  |
- Genes linked to migraine discovered - TRPM8, LRP1 and PRDM16
- We are all mutants
- UN meet delegates says funds for HIV/AIDS control inadequate
- Woman injured in Ramdev crackdown 'very critical'
| Genes linked to migraine discovered - TRPM8, LRP1 and PRDM16 Posted: 13 Jun 2011 02:10 AM PDT ( From http://www.rxpgnews.com ) US scientists have discovered three gene variants linked to migraine, a move that could help understand the cause of severe headaches. Inheriting any one of the three gene variants raises risk of severe headaches by 10 to 15 percent, the researchers said in a study published online by the journal Nature Genetics. The three genes are TRPM8, LRP1 and PRDM16. The first plays a role in sensitivity to cold and pain, while the second is involved in the transmission of signals between neurons, Xinhua reported quoting the study Sunday. 'While migraine remains incompletely understood and its underlying causes difficult to pin down, identifying these three genetic variants helps shed light on the biological roots for this common and debilitating condition,' said lead author of the study, Daniel Chasman, assistant professor in the preventive medicine division at Brigham and Women's Hospital and Harvard Medical School. The researchers based their findings on analysis of genetic data from more than 23,000 women, including over 5,000 migraine sufferers. Although the researchers said the findings are encouraging, they noted that more research is needed to better understand exactly how each of these genes is associated with migraine. Migraine headache, an abnormality in the response of nerve cells to stimuli, is characterized by recurring severe headaches, which often result in nausea as well as sensitivity to light and sound. http://www.rxpgnews.com    |
| Posted: 12 Jun 2011 05:00 AM PDT ( From http://www.rxpgnews.com ) Each one of us receives approximately 60 new mutations in our genome from our parents. This striking value is reported in the first-ever direct measure of new mutations coming from mother and father in whole human genomes published today. For the first time, researchers have been able to answer the questions: how many new mutations does a child have and did most of them come from mum or dad? The researchers measured directly the numbers of mutations in two families, using whole genome sequences from the 1000 Genomes Project. The results also reveal that human genomes, like all genomes, are changed by the forces of mutation: our DNA is altered by differences in its code from that of our parents. Mutations that occur in sperm or egg cells will be 'new' mutations not seen in our parents. Although most of our variety comes from reshuffling of genes from our parents, new mutations are the ultimate source from which new variation is drawn. Finding new mutations is extremely technically challenging as, on average, only 1 in every 100 million letters of DNA is altered each generation. Previous measures of the mutation rate in humans has either averaged across both sexes or measured over several generations. There has been no measure of the new mutations passed from a specific parent to a child among multiple individuals or families. We human geneticists have theorised that mutation rates might be different between the sexes or between people, explains Dr Matt Hurles, Senior Group Leader at the Wellcome Trust Sanger Institute, who co-led the study with scientists at Montreal and Boston, We know now that, in some families, most mutations might arise from the mother, in others most will arise from the father. This is a surprise: many people expected that in all families most mutations would come from the father, due to the additional number of times that the genome needs to be copied to make a sperm, as opposed to an egg. Professor... http://www.rxpgnews.com   |
| UN meet delegates says funds for HIV/AIDS control inadequate Posted: 11 Jun 2011 11:26 PM PDT ( From http://www.rxpgnews.com ) New Delhi, June 11 - Participants at UN General Assembly meeting for HIV/AIDS expressed concern that funding devoted to AIDS responses was still not commensurate with the magnitude of the epidemic and committed to work towards reducing sexual transmission of HIV by 50 percent till 2015. According to an official press release, the UN General Assembly meeting for HIV/AIDS, which ended Friday night at New York, resolved to set specific targets on elimination of the problem through reduction in sexual transmission, elimination of mother to child transmission and putting more number of patients on antiretroviral therapy by 2015. The member countries adopted a resolution on 'Intensifying our efforts to Eliminate HIV/AIDS' at the end of the three-day meeting. Union Health Minister Ghulam Nabi Azad led the Indian delegation at the conference which was attended by more than 3,000 delegates from 192 countries. The release said the countries recognised that HIV and AIDS constituted a global emergency and posed one of the most formidable challenges to progress of societies. 'The members expressed deep concern that funding devoted to HIV and AIDS responses is still not commensurate with the magnitude of the epidemic either nationally or internationally, and that the global financial and economic crises continue to have a negative impact on the HIV and AIDS response at all,' it said. The release said the countries committed to expand efforts to combat tuberculosis, which is a leading cause of death among people living with HIV and promised to accelerate research for a safe, affordable vaccine. --Indo-Asian News Service ps/rah/vt http://www.rxpgnews.com   |
| Woman injured in Ramdev crackdown 'very critical' Posted: 11 Jun 2011 10:22 PM PDT ( From http://www.rxpgnews.com ) New Delhi, June 11 - The condition of 51-year-old Raj Bala is 'very critical', doctors said Saturday, a week after she suffered spinal injuries during police action here against fasting yoga guru Baba Ramdev and his supporters. 'Raj Bala is conscious, her vital parameters are being maintained with pharmacological support and she continues to be on ventilatory support. Her condition is very critical,' N. Shashi Gururaja, medial superintendent of the G.B. Pant Hospital, said in a statement. Raj Bala, a resident of Gurgaon, had undergone surgery June 5 for cervical spinal injuries. Her family blamed police for her critical condition. 'She was not injured in the stampede. She spoke to us at the LNJP - Hospital, and said she was hit by a policeman during the lathicharge at the Ramlila Ground. Her condition is very critical and doctors have told us that she's under observation and anything more can only be said after 72 hours,' Raj Bala's daughter-in-law told IANS. Doctors said the neurological status of Raj Bala remains unchanged and she is a quadriplegic -. The doctors have done decompression and fixation using plate, screw and cage. http://www.rxpgnews.com   |
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